Bernie Mac is a world famous stand-up comedian living the good life in his Los Angeles home complete with beautiful wife, Wanda, and a hi-tech SUV. Life was sweet for the Mac-Man. Then one day, Bernie's sister, in Chicago, is sent to rehab for drug use and her three children: teenage Vanessa, asthmatic wheezing Jordan and sweet, innocent Bryana, are put into Bernie's custody. Raising kids is hard! Especially these kids. They always give poor Uncle Bernie trouble, making him want to "bust their heads 'til the white meat shows".